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Peggi Angel PhD

Peggi Melissa Angel PhD

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(843) 792-8410

angelp@musc.edu

173 Ashley Avenue, BSB 358, Charelston, SC 29425 Room CRI 315

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Rank
  • Professor
College
  • College of Medicine
Department
  • Pharmacology & Immunology
Academic Focus
  • Deciphering the “collagen switch” in disparities of breast cancer. My laboratory has developed novel proteomic workflows that integrate 2D maps of collagen proteins with microscopy studies of breast cancer (Figure 2, based on 2018, Angel et al, Clinical Proteomics Appl). Using these techniques, we are defining critical ancestry-dependent changes in post-translational regulation of collagen types from triple negative breast tumors.
  • Development of high throughput N-glycan assays by imaging mass spectrometry. My laboratory has recently developed a high throughput approach to scan cell N-glycoforms from as few as 3,000 cells. This project further advances approaches to define N-glycan structure through simplified workflows on cells types from cancer and cardiovascular diseases.
  • Extracellular matrix remodeling in liver, lung and cardiovascular disease. This project further advances imaging mass spectrometry of extracellular matrix proteomics by defining cell type niches that produce aberrant collagen. This project focuses specifically on determining new ways to quantitatively measure post-translational regulation and site mutations of collagen type I (COL1A1 and COL1A2) and collagen type III (COL3A1) in liver fibrosis, lung adenocarcinoma, and cardiovascular remodeling
Faculty email addresses should not be used to seek medical advice or to make medical appointments. Please visit MyChart for medical appointments or to contact your provider.

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Biography

Dr. Angel received her PhD from the University of Georgia, and joined the MUSC faculty in 2012 following postdoctoral work studying fetal alcohol and liver disease at Emory University and heart valve development and disease at Vanderbilt University Medical Center.

Dr. Angel’s current research focuses on defining the differences in patterns of extracellular matrix proteins and their modifications in liver inflammation, fibrosis, cirrhosis and hepatocellular carcinoma. Current projects are geared toward discerning differences in the post-translational modification of collagen subtypes in hepatocellular carcinoma and determining whether such differences correlate with variability in clinical outcomes. These studies use tissue imaging proteomics – a unique strength of the MUSC Proteomics and Mass Spectrometry Core – to help understand the histological localization of collagen signatures within a tissue section. The Angel lab also works to develop new high throughput imaging mass spectrometry technologies that help investigators rapidly profile metabolic biomarkers present in patient derived serum, cells and tissues.

 

1999, BS Chemistry, ACS certified

2007, Ph.D, University of Georgia, "Quantative Proteomics in Developmental Biology"

2007-2008 Postdoctoral Fellowship, Emory University "Fetal Alcohol Syndrome & Alcohol-induced Mitochondrial Post-translational Modifications in Liver Disease"

2008-2011 Postdoctoral Fellowship, Vanderbilt University Medical Center "Systems-based Consortium for Organ Design and Engineering: Heart Valves"